Concepts and methods for the dosimetry of radioembolisation of the liver with Y-90-loaded microspheres

This article aims at presenting in a didactic way, dosimetry concepts and methods that are relevant for radio-embolization of the liver with 90 Y-microspheres. The application medical internal radiation dose formalism to is introduced. enables simplified dosimetry, where absorbed given tissue depends on only its mass initial activity. applied single-compartment method, partition model, liver, tumour lung multi-compartment allowing identification multiple tumours. Voxel-based approaches also discussed. allows taking into account non-uniform uptake within compartment, which translates distribution, represented as dose–volume histogram. For this purpose, dose–kernel convolution propagating energy deposition around voxel-sources computationally efficient manner. Alternatively, local-energy preferable when spatial resolution comparable or larger than beta-particle path. Statistical tools may be establishing dose–effect relationships population. These include such logistic regression receiver operator characteristic analysis. Examples illustration purpose. Moreover, control probability modelling can assessed through linear-quadratic model Lea Catcheside counterpart, normal-tissue complication Lyman, suitable parallel structure liver. selectivity microsphere administration sparing, considered concept equivalent uniform dose, examples given. implication microscopic microspheres illustrated toxicity even though it not clinically validated. Finally, we propose reflection therapeutic index (TI), could help tailor treatment planning by determining safety evaluation TI based treatment-specific parameters.